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Alkaline phosphatase in dogs and cats with chronic diarrhoea: a retrospective study.
Serum alkaline phosphatase (SAP) was determined in 45 dogs and 39 cats with chronic diarrhoea by a commercially available assay. Results were compared with results for control animals without signs of gastroenteric disease and the results for healthy animals. No significant difference was found between the SAP levels in the animals with diarrhoea and those in the control groups, even if cats with chronic enteritis had significantly lower values. The normal value for SAP activity in dogs and cats was established to be 20-200 UI/l (median 32.0), and 40-300 UI/l (median 61.5) respectively. The upper normal value for SAP activity in the control animals was established to be 50-200 UI/l (median 77.5), with a normal value for cats of 65-300 UI/l (median 96.5). A significant difference was found between the normal value for SAP in healthy cats and in cats with chronic enteritis. The present study does not confirm that SAP activity is an useful marker of gastroenteric disease in the dogs and cats with chronic diarrhoea and is a useful clinical laboratory test for diagnosis of these diseases.